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An essential trace element that functions within selenoproteins, some of which are enzymes with important antioxidant functions. Glutathione peroxidases, that provide cellular antioxidant defence, and iodothyronine deiodinases that regulate thyroid hormone metabolism to provide hormonal homeostasis in response to variations in iodine intake, are both selenoprotein enzymes. Selenoproteins are also implicated in cell proliferation and survival, redox homeostasis, and the immune response.


OpeN-Global, 2019